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Quote by: Captain Chaos Another example, transgenic rats with components of human immune systems have been created to test for HIV medications. |
And what HIV medications have resulted from transgenic rats?
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Researchers also use primates deliberately infected with SIV for this purpose.
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What HIV medicines have been derived primarily from primates which have been purposely infected with HIV or SIV? And, where are the primates who have been infected with HIV or SIV that have advanced to the stage of AIDS?
Excerpt:Experimenters have been infecting chimps with the HIV virus since 1984. None have become clinically ill, in spite of being infected with several different strains of the virus, having their immune systems altered with drugs, having treatments designed to specifically destroy the cells which are thought to be most active in protecting the body from HIV infection, and being co-infected with other viruses which were presumed to help HIV gain a foothold. Experimenters have even injected human HIV-infected brain tissue directly into chimpanzee brains, but to no avail. Source
With rare exceptions, NHPs(non human primates) don’t develop AIDS when infected with HIV; experimental results cannot be confidently extrapolated to humans. None of 50-plus NHP-tested vaccines (such as “Aidsvax”) has succeeded in humans. Effective anti-HIV drugs were conceived and developed using in vitro and in silico methods, without reliance on animal models. Source
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This is far far more effective research than testing in cell cultures.
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Oh really? Here:
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Epidemiological research and in vitro research led to the discovery of the virus and the mode of transmission. Mary Guinan of the CDC first stated that the new disease must be transmitted via blood or other bodily fluids.Drs. Montagnier and Gallo both conducted in vitro research to isolate the virus. AZT, one of the first medications used to treat AIDS was originally an anti-cancer drug. The efficacy of AZT was first demonstrated in 1985 using test tube research. It went directly to clinical trials without going through the usual animal tests. One reason for this was that it was so well known from it's use in cancer. AZT, 3TC, protease inhibitors, ddI, ddC,d4T, Indinavir, Ritonavir, Saquinavir, Nevirapine and hydroxyurea were alldeveloped from in vitro or test tube methods. Source
and more:
Excerpt:In vitro research on human blood cells, not animal experimentation, revealed the following idiosyncrasies. HIV's efficiency in humans relies on very specific and minuscule aspects of human white blood cells called helper T-cells. These cells have portals on their surface called receptors. These receptors work in tandem with precise proteins to invite HIV into the white blood cell where the virus then reproduces. Receptors can be very species-specific and sometimes vary even within species, which explains why chimpanzees and even some people whose helper T-cells are exposed to HIV never progress to AIDS.
HIV-infected humans who do not progress to AIDS offer very good insights into possible ways of countermanding the disease. Their identity is epidemiologically derived, and in vitro research has isolated the human gene believed responsible for their immunity. The sequencing of the HIV genome was also accomplished via in vitro research. The animal experimentation community claims that AZT and other anti-AIDS medications were developed as a result of animal experiments. However, a look at the history of these drugs' development proves the contrary. All this human data has reliably informed the development of HIV medications and the effort to produce a vaccine. Source
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Eventually, these drugs could be tested in humans, but not until they are proven effective.
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You mean proven effective in animals? Which ones ever have been so and then in humans? What in the past are you basing your hope for the future on?
If animal testing is so efficient then we should have a slew of HIV meds and discoveries concerning HIV developed from animal testing. Well, which ones are they that have emerged from animal testing?