As much as I personally find your proposal to my taste, twoanickel, I think that any action along those lines would certainly be a trigger for a 21st Century Civil War.
Many in the USA self-identify strongly as "Americans" and would take up arms to defend Washington against a reversal of her sovreignty. This includes a large contingent (likely a majority) of the US military. They are well armed and trained and have facilities waiting for "detainees." I don't think I would want to tangle with US soldiers quelling a so-called "revolution" unless there was great public opinion on the side of devolution from federalism.
You are correct about Patrick Henry and George Mason also opposed the constitution as noted in these objections:
http://look.net/gunstonhall/documents/objections.html
Here's another of my favorites from George Mason:
Quote:
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When the same man, or set of men, holds the sword and the purse, there is an end of liberty.
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Why do the Feds get all my extra money every year? Because I have a gun to my head and I fear the consequences of refusing to pay the protection money.